Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

Eleven novel isoquinoline-1-carboxamides (HSR1101~1111) were synthesized and evaluated for their effects on lipopolysaccharide (LPS)-induced production of pro-inflammatory mediators and cell migration in BV2 microglial cells. Three compounds (HSR1101~1103) exhibited the most potent suppression of LP...

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Bibliographic Details
Main Authors: Ha Thi Thu Do, Bich Phuong Bui, Seongrak Sim, Jae-Kyung Jung, Heesoon Lee, Jungsook Cho
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
isoquinoline-1-carboxamide
nuclear factor-kappa B (NF-κB)
mitogen-activated protein kinases (MAPKs)
BV2 microglial cells
intracellular signaling
neuroinflammation
Online Access:https://www.mdpi.com/1422-0067/21/7/2319

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https://www.mdpi.com/1422-0067/21/7/2319

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