ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC

<p>Abstract</p> <p>Background</p> <p>The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis <it>in vitro</it>. In this study, the mechanism...

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Bibliographic Details
Main Authors: Hollingshead Melinda G, Stotler Howard, Yu Sherry X, Stockwin Luke H, Newton Dianne L
Format: Article
Language:English
Published: BMC 2009-02-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/9/63