Non-uniform self-assembly: On the anisotropic architecture of α-synuclein supra-fibrillar aggregates

Abstract Although the function of biopolymer hydrogels in nature depends on structural anisotropy at mesoscopic length scales, the self-assembly of such anisotropic structures in vitro is challenging. Here we show that fibrils of the protein α-synuclein spontaneously self-assemble into structurally...

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Bibliographic Details
Main Authors: Slav A. Semerdzhiev, Volodymyr V. Shvadchak, Vinod Subramaniam, Mireille M. A. E. Claessens
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06532-1