Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

Autophagy is the major mechanism involved in degradation and recycling of intracellular components, and its alterations have been proposed to cause beta cell dysfunction. In this study, we explored the effects of autophagy modulation in human islets under conditions associated to endoplasmic reticul...

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Bibliographic Details
Main Authors: M. Bugliani, S. Mossuto, F. Grano, M. Suleiman, L. Marselli, U. Boggi, P. De Simone, D. L. Eizirik, M. Cnop, P. Marchetti, V. De Tata
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Endocrinology
Subjects:
autophagy
human islets
type 2 diabetes
ER stress
insulin secretion
beta cell dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00052/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00052/full

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