Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs

Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs

Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for the treatment of inflammatory conditions. We recently demonstrated that stimulation of near-organ autonomic nerves to the spleen can be harnessed to modulate the inflammatory response in an anesthetized pig mo...

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Bibliographic Details
Main Authors: David M. Sokal, Alex McSloy, Matteo Donegà, Joseph Kirk, Romain A. Colas, Nikola Dolezalova, Esteban A. Gomez, Isha Gupta, Cathrine T. Fjordbakk, Sebastien Ouchouche, Paul B. Matteucci, Kristina Schlegel, Rizwan Bashirullah, Dirk Werling, Kim Harman, Alison Rowles, Refet Firat Yazicioglu, Jesmond Dalli, Daniel J. Chew, Justin D. Perkins
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
autonomic nervous system
neuromodulation
stimulation
endotoxemia
specialized pro resolving mediators
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.649786/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.649786/full

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