Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries.

Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries.

The present study examined the level of generation of reactive oxygen species (ROS) and roles of inactivation of the phosphatase PTEN and the PI3K/Akt signaling pathway in response to an increase in intramural pressure-induced myogenic cerebral arterial constriction. Step increases in intraluminal p...

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Bibliographic Details
Main Authors: Debebe Gebremedhin, Maia Terashvili, Nadi Wickramasekera, David X Zhang, Nicole Rau, Hiroto Miura, David R Harder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3702596?pdf=render

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http://europepmc.org/articles/PMC3702596?pdf=render

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