Catch-bond mechanism of the bacterial adhesin FimH

Catch-bond mechanism of the bacterial adhesin FimH

Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction between the adhesin FimH and carbohydrate receptors.

Bibliographic Details
Main Authors: Maximilian M. Sauer, Roman P. Jakob, Jonathan Eras, Sefer Baday, Deniz Eriş, Giulio Navarra, Simon Bernèche, Beat Ernst, Timm Maier, Rudi Glockshuber
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10738

Internet

https://doi.org/10.1038/ncomms10738

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