Catch-bond mechanism of the bacterial adhesin FimH

Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction between the adhesin FimH and carbohydrate receptors.

Bibliographic Details
Main Authors:	Maximilian M. Sauer, Roman P. Jakob, Jonathan Eras, Sefer Baday, Deniz Eriş, Giulio Navarra, Simon Bernèche, Beat Ernst, Timm Maier, Rudi Glockshuber
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10738

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spelling	doaj-15996d3b67454979a441ce96b98b7d262021-05-11T11:20:25ZengNature Publishing GroupNature Communications2041-17232016-03-017111310.1038/ncomms10738Catch-bond mechanism of the bacterial adhesin FimHMaximilian M. Sauer0Roman P. Jakob1Jonathan Eras2Sefer Baday3Deniz Eriş4Giulio Navarra5Simon Bernèche6Beat Ernst7Timm Maier8Rudi Glockshuber9Department of Biology, Institute of Molecular Biology and Biophysics, ETHBiozentrum, University of BaselDepartment of Biology, Institute of Molecular Biology and Biophysics, ETHBiozentrum, University of BaselInstitute of Molecular Pharmacy, University of BaselInstitute of Molecular Pharmacy, University of BaselBiozentrum, University of BaselInstitute of Molecular Pharmacy, University of BaselBiozentrum, University of BaselDepartment of Biology, Institute of Molecular Biology and Biophysics, ETHCatch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction between the adhesin FimH and carbohydrate receptors.https://doi.org/10.1038/ncomms10738
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maximilian M. Sauer Roman P. Jakob Jonathan Eras Sefer Baday Deniz Eriş Giulio Navarra Simon Bernèche Beat Ernst Timm Maier Rudi Glockshuber
spellingShingle	Maximilian M. Sauer Roman P. Jakob Jonathan Eras Sefer Baday Deniz Eriş Giulio Navarra Simon Bernèche Beat Ernst Timm Maier Rudi Glockshuber Catch-bond mechanism of the bacterial adhesin FimH Nature Communications
author_facet	Maximilian M. Sauer Roman P. Jakob Jonathan Eras Sefer Baday Deniz Eriş Giulio Navarra Simon Bernèche Beat Ernst Timm Maier Rudi Glockshuber
author_sort	Maximilian M. Sauer
title	Catch-bond mechanism of the bacterial adhesin FimH
title_short	Catch-bond mechanism of the bacterial adhesin FimH
title_full	Catch-bond mechanism of the bacterial adhesin FimH
title_fullStr	Catch-bond mechanism of the bacterial adhesin FimH
title_full_unstemmed	Catch-bond mechanism of the bacterial adhesin FimH
title_sort	catch-bond mechanism of the bacterial adhesin fimh
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-03-01
description	Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction between the adhesin FimH and carbohydrate receptors.
url	https://doi.org/10.1038/ncomms10738
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Catch-bond mechanism of the bacterial adhesin FimH

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