Genomic profiling of colorectal cancer with isolated lung metastasis

Genomic profiling of colorectal cancer with isolated lung metastasis

Abstract Background Metastasis is a major cause of failed colorectal cancer (CRC) treatment. While lung metastasis (LM) is observed in 10–15% of patients with CRC, the genetic mechanisms that cause CRC to metastasize to the lung remain unclear. Methods In this study, we employed whole exome sequenci...

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Bibliographic Details
Main Authors: Nan Zhang, Jiabo Di, Zaozao Wang, Pin Gao, Beihai Jiang, Xiangqian Su
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Lung metastasis
Whole exome sequencing
Somatic single nucleotide variation
Somatic copy number alteration
Clonal evolution
Online Access:http://link.springer.com/article/10.1186/s12935-020-01373-x

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http://link.springer.com/article/10.1186/s12935-020-01373-x

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