Dispirooxindoles Based on 2-Selenoxo-Imidazolidin-4-Ones: Synthesis, Cytotoxicity and ROS Generation Ability

Dispirooxindoles Based on 2-Selenoxo-Imidazolidin-4-Ones: Synthesis, Cytotoxicity and ROS Generation Ability

A regio- and diastereoselective synthesis of two types of dispiro derivatives of 2-selenoxoimidazolidin-4-ones, differing in the position of the nitrogen atom in the central pyrrolidine ring of the spiro-fused system—namely, 2-selenoxodispiro[imidazolidine-4,3′-pyrrolidine-2′,3″-indoline]-2″,5-dione...

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Bibliographic Details
Main Authors: Vladimir K. Novotortsev, Maxim E. Kukushkin, Viktor A. Tafeenko, Dmitry A. Skvortsov, Marina A. Kalinina, Roman V. Timoshenko, Nelly S. Chmelyuk, Liliya A. Vasilyeva, Boris N. Tarasevich, Petr V. Gorelkin, Alexander S. Erofeev, Alexander G. Majouga, Nikolai V. Zyk, Elena K. Beloglazkina
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
selenohydantoins
spiro compounds
indolinones
azomethine ylides
cytotoxicity
ROS generation
Online Access:https://www.mdpi.com/1422-0067/22/5/2613

Internet

https://www.mdpi.com/1422-0067/22/5/2613

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