Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling

Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling

The fight-or-flight response (FFR), a physiological acute stress reaction, involves positive chronotropic and inotropic effects on heart muscle cells mediated through β-adrenoceptor activation. Increased systolic calcium is required to enable stronger heart contractions whereas elevated potassium cu...

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Bibliographic Details
Main Authors: Ilaria Piccini, Edda Fehrmann, Stefan Frank, Frank U. Müller, Boris Greber, Guiscard Seebohm
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Physiology
Subjects:
adrenergic stress
KCNQ1
ion channel transport
fast recycling
stress-induced arrhythmia
hiPSC-derived cardiomyocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00705/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00705/full

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