Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-selective Lsd1 ablation induces a shift from oxidativ...

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Bibliographic Details
Main Authors: Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
lysine-specific demethylase 1
brown adipose tissue
epigenetics
lipid metabolism
white adipose tissue
adipocyte
CoREST
thermogenesis
obesity
carbohydrate metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631292X

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http://www.sciencedirect.com/science/article/pii/S221112471631292X

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