Cell-Cycle-Dependent Reconfiguration of the DNA Methylome during Terminal Differentiation of Human B Cells into Plasma Cells

Cell-Cycle-Dependent Reconfiguration of the DNA Methylome during Terminal Differentiation of Human B Cells into Plasma Cells

Molecular mechanisms underlying terminal differentiation of B cells into plasma cells are major determinants of adaptive immunity but remain only partially understood. Here we present the transcriptional and epigenomic landscapes of cell subsets arising from activation of human naive B cells and dif...

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Bibliographic Details
Main Authors: Gersende Caron, Mourad Hussein, Marta Kulis, Céline Delaloy, Fabrice Chatonnet, Amandine Pignarre, Stéphane Avner, Maud Lemarié, Elise A. Mahé, Núria Verdaguer-Dot, Ana C. Queirós, Karin Tarte, José I. Martín-Subero, Gilles Salbert, Thierry Fest
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cell Reports
Subjects:
B cell differentiation
plasmablast
plasma cell differentiation
DNA methylation
5hmC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715010761

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http://www.sciencedirect.com/science/article/pii/S2211124715010761

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