Integrating expert opinion with clinical trial data to extrapolate long-term survival: a case study of CAR-T therapy for children and young adults with relapsed or refractory acute lymphoblastic leukemia

Integrating expert opinion with clinical trial data to extrapolate long-term survival: a case study of CAR-T therapy for children and young adults with relapsed or refractory acute lymphoblastic leukemia

Abstract Background Long-term clinical outcomes are necessary to assess the cost-effectiveness of new treatments over a lifetime horizon. Without long-term clinical trial data, current practice to extrapolate survival beyond the trial period involves fitting alternative parametric models to the obse...

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Bibliographic Details
Main Authors: Shannon Cope, Dieter Ayers, Jie Zhang, Katharine Batt, Jeroen P. Jansen
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Medical Research Methodology
Subjects:
Survival
Expert elicitation
Pediatric
Leukemia
Tisagenlecleucel
Online Access:http://link.springer.com/article/10.1186/s12874-019-0823-8

Internet

http://link.springer.com/article/10.1186/s12874-019-0823-8

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