Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

There has been significant interest in the bioactivity of the natural product psammaplin A, most recently as a potent and isoform selective HDAC inhibitor. Here we report our preliminary studies on thioester HDAC inhibitors derived from the active monomeric (thiol) form of psammaplin A, as a means t...

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Bibliographic Details
Main Authors: Matthias G. J. Baud, Thomas Leiser, Vanessa Petrucci, Mekala Gunaratnam, Stephen Neidle, Franz-Josef Meyer-Almes, Matthew J. Fuchter
Format: Article
Language:English
Published: Beilstein-Institut 2013-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
epigenetics
histone deacetylase
natural product
prodrug
psammaplin A
thioester
Online Access:https://doi.org/10.3762/bjoc.9.11

Internet

https://doi.org/10.3762/bjoc.9.11

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