Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors
There has been significant interest in the bioactivity of the natural product psammaplin A, most recently as a potent and isoform selective HDAC inhibitor. Here we report our preliminary studies on thioester HDAC inhibitors derived from the active monomeric (thiol) form of psammaplin A, as a means t...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Beilstein-Institut
2013-01-01
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Series: | Beilstein Journal of Organic Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.3762/bjoc.9.11 |