Tropheryma whipplei, the agent of Whipple's disease, affects the early to late phagosome transition and survives in a Rab5- and Rab7-positive compartment.

Tropheryma whipplei, the agent of Whipple's disease, affects the early to late phagosome transition and survives in a Rab5- and Rab7-positive compartment.

Tropheryma whipplei, the agent of Whipple's disease, inhibits phago-lysosome biogenesis to create a suitable niche for its survival and replication in macrophages. To understand the mechanism by which it subverts phagosome maturation, we used biochemical and cell biological approaches to purify...

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Bibliographic Details
Main Authors: Giovanna Mottola, Nicolas Boucherit, Virginie Trouplin, Abdoulaye Oury Barry, Philippe Soubeyran, Jean-Louis Mege, Eric Ghigo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3933534?pdf=render

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http://europepmc.org/articles/PMC3933534?pdf=render

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