A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy

A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy

Background: The prevalence of HER2 alterations in pan-cancer indicates a broader range of application of HER2-targeted therapies; however, biomarkers for such therapies are still insufficient and limited to breast cancer and gastric cancer. Methods: Using multi-omics data from The Cancer Genome Atla...

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Bibliographic Details
Main Authors: Ziteng Li, Siyuan Chen, Wanjing Feng, Yixiao Luo, Hongyan Lai, Qin Li, Bingqiu Xiu, Yuchen Li, Yan Li, Shenglin Huang, Xiaodong Zhu
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:EBioMedicine
Subjects:
HER2-amplification
HER2-enriched subtype
Pan-cancer
Biomarker
Multi-omics analysis
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420304503

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http://www.sciencedirect.com/science/article/pii/S2352396420304503

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