Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing long 3'UTRs to perform dual roles in mRNA quality control and gene expression regulation. However, expansion of vertebrate 3'UTR functions has required a physical expansion of 3'UTR lengths, complicating the proc...

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Bibliographic Details
Main Authors: Zhiyun Ge, Bao Lin Quek, Karen L Beemon, J Robert Hogg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
PTBP1
Rous sarcoma virus
retrovirus
nonsense-mediated mRNA decay
3'UTR
Online Access:https://elifesciences.org/articles/11155

Internet

https://elifesciences.org/articles/11155

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