Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy

Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy

Leprosy reactions are responsible for incapacities in leprosy and represent the major cause of permanent neuropathy. The identification of biomarkers able to identify patients more prone to develop reaction could contribute to adequate clinical management and the prevention of disability. Reversal r...

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Bibliographic Details
Main Authors: Mayara Garcia de Mattos Barbosa, Bruno Jorge de Andrade Silva, Tayná Quintella Assis, Rhana Berto da Silva Prata, Helen Ferreira, Priscila Ribeiro Andrade, Jéssica Araújo da Paixão de Oliveira, Gilberto Marcelo Sperandio da Silva, José Augusto da Costa Nery, Euzenir Nunes Sarno, Roberta Olmo Pinheiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
leprosy
multibacillary patients
reversal reaction
autophagy
inflammasome
Mycobacterium leprae
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01223/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01223/full

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