Single-Cell Transcriptomics Supports a Role of <i>CHD8</i> in Autism

Single-Cell Transcriptomics Supports a Role of <i>CHD8</i> in Autism

Chromodomain helicase domain 8 (<i>CHD8</i>) is one of the most frequently mutated and most penetrant genes in the autism spectrum disorder (ASD). Individuals with <i>CHD8</i> mutations show leading symptoms of autism, macrocephaly, and facial dysmorphisms. The molecular and...

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Bibliographic Details
Main Authors: Anke Hoffmann, Dietmar Spengler
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
ASD
CHD8
single-cell sequencing
excitatory/inhibitory imbalance
neocorticogenesis
CRISPR/Cas9 editing
Online Access:https://www.mdpi.com/1422-0067/22/6/3261

Internet

https://www.mdpi.com/1422-0067/22/6/3261

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