Detection of Lymph Node Metastases in Human Colorectal Cancer by Using 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence with Spectral Unmixing

Detection of Lymph Node Metastases in Human Colorectal Cancer by Using 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence with Spectral Unmixing

Accurate evaluation of metastatic lymph nodes (LNs) is indispensable for adequate treatment of colorectal cancer (CRC) patients. Here, we demonstrate detection of metastases of human CRC in removed fresh LNs using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence. A spectra...

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Bibliographic Details
Main Authors: Kenichi Harada, Yoshinori Harada, Masatomo Beika, Noriaki Koizumi, Koji Inoue, Yasutoshi Murayama, Yoshiaki Kuriu, Masayoshi Nakanishi, Takeo Minamikawa, Yoshihisa Yamaoka, Ping Dai, Akio Yanagisawa, Eigo Otsuji, Tetsuro Takamatsu
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer
5-aminolevulinic acid
lymph node metastasis
spectral unmixing
protoporphyrin IX
Online Access:http://www.mdpi.com/1422-0067/14/11/23140

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http://www.mdpi.com/1422-0067/14/11/23140

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