Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps

Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps

Abstract Background Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression of MUC5AC, the major macro-molecular constituent of airway mucus, the p...

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Bibliographic Details
Main Authors: Jian Jiao, Tao Zhang, Yu Zhang, Jingyun Li, Min Wang, Ming Wang, Ying Li, Xiangdong Wang, Luo Zhang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
Chronic rhinosinusitis with nasal polyps
Epidermal growth factor
Human nasal epithelial cells (HNECs)
MUC5AC
Transmembrane protein 16A (TMEM16A)
Phosphoinositide 3-kinase (PI3K)
Online Access:http://link.springer.com/article/10.1186/s13223-020-00440-2

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http://link.springer.com/article/10.1186/s13223-020-00440-2

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