Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology

Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology

An important role for plexinD1 in thymic development is inferred from studies of germline Plxnd1 knockout (KO) mice where mislocalized CD69+ thymocytes as well as ectopic thymic subcapsular medullary structures were observed. Given embryonic lethality of the Plxnd1-/- genotype, fetal liver transplan...

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Bibliographic Details
Main Authors: Young Il Choi, Jonathan S Duke-Cohan, Jing eTan, Jingang eGui, Manvendra K. Singh, Jonathan A Epstein, Ellis L Reinherz
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
Angiogenesis
thymic epithelial cells
Plexind1
thymic development
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00392/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00392/full

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