Redox modifications of cysteine residues regulate the cytokine activity of HMGB1

Redox modifications of cysteine residues regulate the cytokine activity of HMGB1

Abstract Background High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is passively released during cell death and secreted by activated cells of many lineages. HMGB1 contains three conserved redox-sensitive cysteine residues: cysteines in po...

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Bibliographic Details
Main Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Medicine
Subjects:
HMGB1
Isoforms
TLR4
Redox
Cytokine
Receptor
Online Access:https://doi.org/10.1186/s10020-021-00307-1

Internet

https://doi.org/10.1186/s10020-021-00307-1

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