The majority of A-to-I RNA editing is not required for mammalian homeostasis

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Abstract Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes. A-to-I editing can change the protein coding potential of a transcript and alter RNA splicing, miRNA biology, RNA secondary st...

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Bibliographic Details
Main Authors: Alistair M. Chalk, Scott Taylor, Jacki E. Heraud-Farlow, Carl R. Walkley
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Genome Biology
Subjects:
A-to-I editing
ADAR1
ADAR2
RNA editing
Epitranscriptome
RNA modification
Online Access:https://doi.org/10.1186/s13059-019-1873-2

Internet

https://doi.org/10.1186/s13059-019-1873-2

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