Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches

Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer various gain-of-function (GOF) activities that impacts molecules and pathways now regarded as central for tumor development and progression. Although the complete impact of GOF is still far from being fully under...

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Bibliographic Details
Main Authors: Eduardo Alvarado-Ortiz, Karen Griselda de la Cruz-López, Jared Becerril-Rico, Miguel Angel Sarabia-Sánchez, Elizabeth Ortiz-Sánchez, Alejandro García-Carrancá
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
p53
gain of function
oncogenic pathways
metabolic reprogramming
stemness
chemo-resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.607670/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.607670/full

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