Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association

Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association

Abstract Background Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates with improved relapse-free survival in ER+...

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Bibliographic Details
Main Authors: Eva Tonsing-Carter, Kyle M. Hernandez, Caroline R. Kim, Ryan V. Harkless, Alyce Oh, Kathleen R. Bowie, Diana C. West-Szymanski, Mayra A. Betancourt-Ponce, Bradley D. Green, Ricardo R. Lastra, Gini F. Fleming, Sarat Chandarlapaty, Suzanne D. Conzen
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Estrogen receptor
Glucocorticoid receptor
Mutant activated estrogen receptor
Nuclear receptor crosstalk
Chromatin association
Online Access:http://link.springer.com/article/10.1186/s13058-019-1164-6

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http://link.springer.com/article/10.1186/s13058-019-1164-6

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