Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

Substrate-binding proteins (SBPs) are associated with ATP-binding cassette importers and switch from an open to a closed conformation upon substrate binding, providing specificity for transport. We investigated the effect of substrates on the conformational dynamics of six SBPs and the impact on tra...

Full description

Bibliographic Details
Main Authors: Marijn de Boer, Giorgos Gouridis, Ruslan Vietrov, Stephanie L Begg, Gea K Schuurman-Wolters, Florence Husada, Nikolaos Eleftheriadis, Bert Poolman, Christopher A McDevitt, Thorben Cordes
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
smFRET
ABC transporter
membrane transport
substrate-binding protein
biophysics
single-molecule
Online Access:https://elifesciences.org/articles/44652

Internet

https://elifesciences.org/articles/44652

Similar Items