Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis

Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis

Objective: to identify new single-nucleotide polymorphisms (SNPs) in genes encoding proteins involved in methotrexate (MTX) metabolism and to evaluate the associations of these SNPs with MTX toxicity or intolerance in a southern Spanish cohort of patients with rheumatoid arthritis (RA). Methods: An...

Full description

Bibliographic Details
Main Authors: Alejandro Escudero-Contreras, Clementina López-Medina, Eduardo Collantes-Estévez, Rafaela Ortega-Castro, Jerusalem Calvo-Gutiérrez, Natalia Mena-Vázquez, Blanca Panero-Lamothe, Bárbara Manzanares-Martín, Rafael Cáliz-Cáliz, Alberto Jiménez-Morales, Mayte Ruiz-Jiménez, Pilar Font-Ugalde
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Clinical Medicine
Subjects:
methotrexate
rheumatoid arthritis
genetics
biomarkers
Online Access:https://www.mdpi.com/2077-0383/10/18/4070

Internet

https://www.mdpi.com/2077-0383/10/18/4070

Similar Items