Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification

Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification

Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNAs as building blocks for translation. Each of the aaRS families plays a pivotal role in protein biosynthesis and is indispensable for cell growth and survival. In addition, aaRSs in higher s...

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Bibliographic Details
Main Authors: Pengfei Fang, Min Guo
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Life
Subjects:
aminoacyl-tRNA synthetase (aaRS)
inhibitor
evolution
protein-ligand interaction
structure conservation
species specificity
Online Access:http://www.mdpi.com/2075-1729/5/4/1703

Internet

http://www.mdpi.com/2075-1729/5/4/1703

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