Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification
Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNAs as building blocks for translation. Each of the aaRS families plays a pivotal role in protein biosynthesis and is indispensable for cell growth and survival. In addition, aaRSs in higher s...
Main Authors: | Pengfei Fang, Min Guo |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-12-01
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Series: | Life |
Subjects: | |
Online Access: | http://www.mdpi.com/2075-1729/5/4/1703 |
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