Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression

Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression

Juvenile idiopathic arthritis (JIA) represents joint inflammation with an unknown cause that starts before the age of 16, resulting in stiff and painful joints. In addition, JIA patients often report symptoms of sickness behavior. Recent animal studies suggest that proinflammatory cytokines produce...

Full description

Bibliographic Details
Main Authors: Gerdien A. H. Korte-Bouws, Eline Albers, Marije Voskamp, Hendrikus Hendriksen, Lidewij R. de Leeuw, Onur Güntürkün, Sytze de Roock, Sebastiaan J. Vastert, S. Mechiel Korte
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceuticals
Subjects:
arthritis
inflammation
sickness behavior
fatigue
biomarkers
indoleamine-2,3-dioxygenase (IDO)
guanosinetriphosphate–cyclohydrolase-1 (GTP–CH1)
tetrahydrobiopterin (BH4)
tryptophan
kynurenine
tyrosine
neopterin
phenylalanine
Online Access:http://www.mdpi.com/1424-8247/12/1/9

Internet

http://www.mdpi.com/1424-8247/12/1/9

Similar Items