The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

TGR5 (Gpbar1) is a G protein-coupled receptor responsive to bile acids (BAs), which is expressed in different non-parenchymal cells of the liver, including biliary epithelial cells, liver-resident macrophages, sinusoidal endothelial cells (LSECs), and activated hepatic stellate cells (HSCs). Mice wi...

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Bibliographic Details
Main Authors: Caroline Klindt, Maria Reich, Birte Hellwig, Jan Stindt, Jörg Rahnenführer, Jan G. Hengstler, Karl Köhrer, Kristina Schoonjans, Dieter Häussinger, Verena Keitel
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
bile acids
endothelin-1
sinusoidal endothelial cells
hepatic stellate cells
portal hypertension
Online Access:https://www.mdpi.com/2073-4409/8/11/1467

Internet

https://www.mdpi.com/2073-4409/8/11/1467

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