Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

Mutations in the synaptic gene SHANK3 lead to a neurodevelopmental disorder known as Phelan-McDermid syndrome (PMS). PMS is a relatively common monogenic and highly penetrant cause of autism spectrum disorder (ASD) and intellectual disability (ID), and frequently presents with attention deficits. Th...

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Bibliographic Details
Main Authors: Hala Harony-Nicolas, Maya Kay, Johann du Hoffmann, Matthew E Klein, Ozlem Bozdagi-Gunal, Mohammed Riad, Nikolaos P Daskalakis, Sankalp Sonar, Pablo E Castillo, Patrick R Hof, Matthew L Shapiro, Mark G Baxter, Shlomo Wagner, Joseph D Buxbaum
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
autism spectrum disorder
Shank3
Phelan McDermid Syndrome
oxytocin
social behavior
attention
Online Access:https://elifesciences.org/articles/18904

Internet

https://elifesciences.org/articles/18904

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