Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis

Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis

Abstract Background Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in the recipients. Therefore, MSCs cultured in serum-free media (SF-MSCs) ar...

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Bibliographic Details
Main Authors: Shun Takao, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Shinya Takahashi, Ayumu Nakashima, Noboru Hattori
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cells
Serum-free
Bleomycin
Pulmonary fibrosis
Regulatory T cells
Interleukin-6
Online Access:https://doi.org/10.1186/s13287-021-02574-5

Internet

https://doi.org/10.1186/s13287-021-02574-5

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