hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis

Abstract Background Human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes are recognized as novel cell-free therapeutic agents for inflammatory bowel disease (IBD), a condition caused by dysregulated intestinal mucosal immunity. In this event, macrophage pyroptosis, a process of cell...

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Bibliographic Details
Main Authors: Xiu Cai, Zhi-yu Zhang, Jin-tao Yuan, Dickson Kofi Wiredu Ocansey, Qiang Tu, Xu Zhang, Hui Qian, Wen-rong Xu, Wei Qiu, Fei Mao
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Stem Cell Research & Therapy
Subjects:
hucMSC-derived exosomes
miR-378a-5p
IBD
NLRP3
Macrophage
Pyroptosis
Online Access:https://doi.org/10.1186/s13287-021-02492-6

Internet

https://doi.org/10.1186/s13287-021-02492-6

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