Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs

Animal models are essential for evaluating the toxicity of chemical warfare nerve agents (CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical countermeasures. The Göttingen minipig is increasingly used for toxicological studies because it has anatomical and phys...

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Bibliographic Details
Main Authors: Lucille Lumley, Fu Du, Brenda Marrero-Rosado, Michael Stone, Zora-Maya Keith, Caroline Schultz, Kimberly Whitten, Katie Walker, Cindy Acon-Chen, Linnzi Wright, Tsung-Ming Shih
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Toxicology Reports
Subjects:
Chemical warfare nerve agent
Göttingen minipig
Median lethal dose
Visual system
Seizure
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750021000810

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http://www.sciencedirect.com/science/article/pii/S2214750021000810

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