The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are incompletely understood. Here we show that two related s...

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Bibliographic Details
Main Authors: Yongjie Wei, Zhenyi An, Zhongju Zou, Rhea Sumpter Jr, Minfei Su, Xiao Zang, Sangita Sinha, Matthias Gaestel, Beth Levine
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-02-01
Series:eLife
Subjects:
autophagy
Beclin 1
BCL2
MAPK signaling
starvation
Online Access:https://elifesciences.org/articles/05289

Internet

https://elifesciences.org/articles/05289

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