U4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity.

U4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity.

The viral RNA-dependent RNA polymerase has been found to contribute to efficient replication in mammalian systems and to the high pathogenicity of H5N1 influenza A virus in humans and other mammals. The terminal untranslated regions of the viral segments perform functions such as polyadenylation and...

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Bibliographic Details
Main Authors: Wei Sun, Jing Li, Pengfei Han, Yinhui Yang, Xiaoping Kang, Yuchang Li, Jiaming Li, Yu Zhang, Xiaoyan Wu, Tao Jiang, Chengfeng Qin, Yi Hu, Qingyu Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3968160?pdf=render

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http://europepmc.org/articles/PMC3968160?pdf=render

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