Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency

Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency

Chronic lymphocytic leukemia (CLL) can be divided into prognostically distinct subsets with stereotyped or non-stereotyped, mutated or unmutated B cell receptors (BCRs). Individual subsets vary in antigen specificity and origin, but the impact of antigenic pressure on the CLL BCR repertoire remains...

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Bibliographic Details
Main Authors: Simar Pal Singh, Marjolein J. W. de Bruijn, Mariana P. de Almeida, Ruud W. J. Meijers, Lars Nitschke, Anton W. Langerak, Saravanan Y. Pillai, Ralph Stadhouders, Rudi W. Hendriks
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
B cell receptors
T cell help
BCR signaling
Bruton's tyrosine kinase
chronic lymphocytic leukemia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01996/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01996/full

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