Structure–Activity Relationship of Aloperine Derivatives as New Anti–Liver Fibrogenic Agents
Twenty-seven novel 12<i>N</i>-substituted aloperine derivatives were synthesized and investigated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells, taking aloperine (<b>1</b>) as the hit. A structure-activity relationship...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-10-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/21/4977 |