Structure–Activity Relationship of Aloperine Derivatives as New Anti–Liver Fibrogenic Agents

Twenty-seven novel 12<i>N</i>-substituted aloperine derivatives were synthesized and investigated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells, taking aloperine (<b>1</b>) as the hit. A structure-activity relationship...

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Bibliographic Details
Main Authors: Kun Wang, Zhihao Guo, Yunyang Bao, Yudong Pang, Yinghong Li, Hongwei He, Danqing Song
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/25/21/4977