Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells

Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells

While genetic traits and epigenetic modifications mainly encode cell type-specific effector functions, the eventual outcome is also prone to modulation by post-transcriptional regulation mechanisms. T cells are a powerful model for the investigation of such modulatory effects, as common precursor ce...

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Bibliographic Details
Main Authors: Marlene C. Gerner, Laura Niederstaetter, Liesa Ziegler, Andrea Bileck, Astrid Slany, Lukas Janker, Ralf L.J. Schmidt, Christopher Gerner, Giorgia Del Favero, Klaus G. Schmetterer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
metabolism
mitochondria
primary human lymphocytes
proteome profile
reactive oxygen species
T cell activation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00727/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00727/full

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