Development and Evaluation of Multifunctional Poly(Lactic-co-glycolic acid) Nanoparticles Embedded in Carboxymethyl β-Glucan Porous Microcapsules as a Novel Drug Delivery System for Gefitinib

Development and Evaluation of Multifunctional Poly(Lactic-co-glycolic acid) Nanoparticles Embedded in Carboxymethyl β-Glucan Porous Microcapsules as a Novel Drug Delivery System for Gefitinib

In this study, a new kind of folic acid (FA)-conjugated and chitosan (CS)-coated poloxamer 407 (P407)/poly(lactic-<i>co</i>-glycolic acid) (PLGA) nanoparticles (NPs), FCPP NPs, were prepared, and further micro-encapsulated by carboxymethyl β-glucan microcapsules (MCs) to produce a multif...

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Bibliographic Details
Main Authors: Xiaonan Li, Jinglei Wang, Shang Li, Zhaorong Liu, Zhiru Zheng, Yanzhuo Zhang
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceutics
Subjects:
nanocomposites
controlled delivery
dual-particulate
cellular uptake
carboxymethyl β-glucan
chemotherapeutic drugs
Online Access:https://www.mdpi.com/1999-4923/11/9/469

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https://www.mdpi.com/1999-4923/11/9/469

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