Low-Dose LPS Induces Tolerogenic Treg Skewing in Asthma

Low-Dose LPS Induces Tolerogenic Treg Skewing in Asthma

The mechanism(s) underlying endotoxin tolerance in asthma remain elusive. As the endotoxin lipopolysaccharide (LPS) affects the expression of the regulatory T-cell (Treg)-suppressive glucocorticoid-induced tumor necrosis factor receptor ligand (GITRL) on antigen-presenting dendritic cells (DCs), we...

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Bibliographic Details
Main Authors: Fengxia Ding, Bo Liu, Chao Niu, Ting Wang, Yaping Wang, Gang Geng, Daiyin Tian, Jihong Dai, Zhou Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
asthma
LPS
endotoxin tolerance
TLR4
GITRL
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02150/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02150/full

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