Protective Effects of Sacubitril/Valsartan on Cardiac Fibrosis and Function in Rats With Experimental Myocardial Infarction Involves Inhibition of Collagen Synthesis by Myocardial Fibroblasts Through Downregulating TGF-β1/Smads Pathway

Protective Effects of Sacubitril/Valsartan on Cardiac Fibrosis and Function in Rats With Experimental Myocardial Infarction Involves Inhibition of Collagen Synthesis by Myocardial Fibroblasts Through Downregulating TGF-β1/Smads Pathway

Objectives: To investigate the effect and mechanism of sacubitril/valsartan on myocardial fibrosis in rats following experimental myocardial infarction and in TGF-β1-treated myocardial fibroblasts.Methods: Male Sprague-Dawley (SD) rats were subjected to coronary artery ligation to establish myocardi...

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Bibliographic Details
Main Authors: Meifang Wu, Yanguang Guo, Ying Wu, Kaizu Xu, Liming Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
sacubitril/valsartan
myocardial infarction
myocardial fibrosis
transforming growth factor-β1
myocardial fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.696472/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.696472/full

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