AIF3 splicing switch triggers neurodegeneration

AIF3 splicing switch triggers neurodegeneration

Abstract Background Apoptosis-inducing factor (AIF), as a mitochondrial flavoprotein, plays a fundamental role in mitochondrial bioenergetics that is critical for cell survival and also mediates caspase-independent cell death once it is released from mitochondria and translocated to the nucleus unde...

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Bibliographic Details
Main Authors: Shuiqiao Liu, Mi Zhou, Zhi Ruan, Yanan Wang, Calvin Chang, Masayuki Sasaki, Veena Rajaram, Andrew Lemoff, Kalyani Nambiar, Jennifer E. Wang, Kimmo J. Hatanpaa, Weibo Luo, Ted M. Dawson, Valina L. Dawson, Yingfei Wang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Neurodegeneration
Subjects:
AIF
Mitochondrial dysfunction
AIF3 splicing
Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-021-00442-7

Internet

https://doi.org/10.1186/s13024-021-00442-7

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