Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
The gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system.
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Nature Publishing Group
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19931-2 |
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doaj-161cd6205c514a068009fecb2385aea82021-01-31T12:59:19ZengNature Publishing GroupNature Communications2041-17232020-12-0111111510.1038/s41467-020-19931-2Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid systemGrégoire Chevalier0Eleni Siopi1Laure Guenin-Macé2Maud Pascal3Thomas Laval4Aline Rifflet5Ivo Gomperts Boneca6Caroline Demangel7Benoit Colsch8Alain Pruvost9Emeline Chu-Van10Aurélie Messager11François Leulier12Gabriel Lepousez13Gérard Eberl14Pierre-Marie Lledo15Microenvironment and Immunity Unit, INSERM U1224, Institut PasteurPerception and Memory Unit, CNRS UMR3571, Institut PasteurImmunobiology of Infection Unit, INSERM U1221, Institut PasteurMicroenvironment and Immunity Unit, INSERM U1224, Institut PasteurImmunobiology of Infection Unit, INSERM U1221, Institut PasteurBiology and Genetics of Bacterial Cell Wall Unit, CNRS UMR2001, INSERM, Equipe Avenir, Institut PasteurBiology and Genetics of Bacterial Cell Wall Unit, CNRS UMR2001, INSERM, Equipe Avenir, Institut PasteurImmunobiology of Infection Unit, INSERM U1221, Institut PasteurUniversité Paris Saclay, CEA, INRAE, Médicaments et Technologie pour la Santé (MTS)Université Paris Saclay, CEA, INRAE, Médicaments et Technologie pour la Santé (MTS)Université Paris Saclay, CEA, INRAE, Médicaments et Technologie pour la Santé (MTS)Université Paris Saclay, CEA, INRAE, Médicaments et Technologie pour la Santé (MTS)Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5242Perception and Memory Unit, CNRS UMR3571, Institut PasteurMicroenvironment and Immunity Unit, INSERM U1224, Institut PasteurPerception and Memory Unit, CNRS UMR3571, Institut PasteurThe gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system.https://doi.org/10.1038/s41467-020-19931-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Grégoire Chevalier Eleni Siopi Laure Guenin-Macé Maud Pascal Thomas Laval Aline Rifflet Ivo Gomperts Boneca Caroline Demangel Benoit Colsch Alain Pruvost Emeline Chu-Van Aurélie Messager François Leulier Gabriel Lepousez Gérard Eberl Pierre-Marie Lledo |
| spellingShingle |
Grégoire Chevalier Eleni Siopi Laure Guenin-Macé Maud Pascal Thomas Laval Aline Rifflet Ivo Gomperts Boneca Caroline Demangel Benoit Colsch Alain Pruvost Emeline Chu-Van Aurélie Messager François Leulier Gabriel Lepousez Gérard Eberl Pierre-Marie Lledo Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system Nature Communications |
| author_facet |
Grégoire Chevalier Eleni Siopi Laure Guenin-Macé Maud Pascal Thomas Laval Aline Rifflet Ivo Gomperts Boneca Caroline Demangel Benoit Colsch Alain Pruvost Emeline Chu-Van Aurélie Messager François Leulier Gabriel Lepousez Gérard Eberl Pierre-Marie Lledo |
| author_sort |
Grégoire Chevalier |
| title |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_short |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_full |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_fullStr |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_full_unstemmed |
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| title_sort |
effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-12-01 |
| description |
The gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system. |
| url |
https://doi.org/10.1038/s41467-020-19931-2 |
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