<i>N</i>-Skatyltryptamines—Dual 5-HT<sub>6</sub>R/D<sub>2</sub>R Ligands with Antipsychotic and Procognitive Potential

<i>N</i>-Skatyltryptamines—Dual 5-HT<sub>6</sub>R/D<sub>2</sub>R Ligands with Antipsychotic and Procognitive Potential

A series of <i>N</i>-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub>, 5-HT<sub>6</sub>, and D<sub>2</sub>...

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Bibliographic Details
Main Authors: Agata Hogendorf, Adam S. Hogendorf, Rafał Kurczab, Grzegorz Satała, Bernadeta Szewczyk, Paulina Cieślik, Gniewomir Latacz, Jadwiga Handzlik, Tomasz Lenda, Katarzyna Kaczorowska, Jakub Staroń, Ryszard Bugno, Beata Duszyńska, Andrzej J. Bojarski
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
<i>N</i>-skatyltryptamine
tryptamine
D<sub>2</sub>/5-HT<sub>6</sub>R receptor agonist/antagonist
antipsychotic
precognitive
halogen bond
Online Access:https://www.mdpi.com/1420-3049/26/15/4605

Internet

https://www.mdpi.com/1420-3049/26/15/4605

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