IL-23R is epigenetically regulated and modulated by chemotherapy in Non-Small Cell Lung Cancer

IL-23R is epigenetically regulated and modulated by chemotherapy in Non-Small Cell Lung Cancer

The IL-23/IL-23R signalling axis is an important inflammatory pathway, involved in the stimulation and regulation of the T helper (Th) 17 lymphocytes, resulting in the production of IL-17. Aside from auto-immunity, this cytokine has also been linked to carcinogenesis and polymorphisms in the IL-23R...

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Bibliographic Details
Main Authors: Anne-Marie eBaird, Eilis eDockry, Anne eDaly, Emma eStack, Derek G. Doherty, Kenneth J. O'Byrne, Steven G. Gray
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Oncology
Subjects:
Acetylation
Methylation
epigenetics
Non-small cell lung cancer
IL-23R
Apilimod
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00162/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00162/full

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