Atractylenolide-I Sensitizes Triple-Negative Breast Cancer Cells to Paclitaxel by Blocking CTGF Expression and Fibroblast Activation

Atractylenolide-I Sensitizes Triple-Negative Breast Cancer Cells to Paclitaxel by Blocking CTGF Expression and Fibroblast Activation

This investigation was conducted to elucidate whether atractylenolide-I (ATL-1), which is the main component of Atractylodes macrocephala Koidz, can sensitize triple-negative breast cancer (TNBC) cells to paclitaxel and investigate the possible mechanism involved. We discovered that ATL-1 could inhi...

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Bibliographic Details
Main Authors: Meng Wang, Xue-Zhen Li, Ming-Xing Zhang, Qian-Yu Ye, Ying-Xia Chen, Xu Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
CTGF
fibroblast
chemoresistance
microenvironment
paclitaxel
triple-negative breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.738534/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.738534/full

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